Table 3.
Association of HER2/HER3 dimerisation levels with biomarker expression in breast cancer
| HER2/HER3 Status | ||||||
|---|---|---|---|---|---|---|
| Biomarker | Unselected series | HER2+ series | ||||
| Low (%) | High (%) | p value (χ 2) | Low (%) | High (%) | p value (χ 2) | |
| Bcl-2 | ||||||
| Negative | 207 (41.0) | 53 (75.7) | <0.001 (29.925) | 32 (47.1) | 80 (66.1) | 0.010 (6.549) |
| Positive | 298 (59.0) | 17 (24.3) | 36 (52.9) | 41 (33.9) | ||
| pAkt | ||||||
| Negative | 121 (25.4) | 11 (15.5) | 0.044 (3.295) | 11 (29.7) | 11 (19.6) | 0.263 (1.255) |
| Positive | 356 (74.6) | 60 (84.5) | 26 (70.3) | 45 (80.4) | ||
| PI3K | ||||||
| Negative | 122 (22.1) | 7 (8.6) | <0.001 (15.942) | 4 (5.8) | 5 (3.7) | 0.105 (4.512) |
| Moderate | 143 (25.9) | 13 (16.0) | 12 (17.4) | 11 (8.2) | ||
| Strong | 288 (52.0) | 61 (75.3) | 53 (76.8) | 118 (88.1) | ||
| p21 | ||||||
| Negative | 99 (79.2) | 10 (90.9) | 0.351 (0.871) | 17 (45.9) (2.9) | 12 (23.5) | 0.027 (4.877) |
| Positive | 26 (20.8) | 1 (9.1) | 20 (54.1) | 39 (76.5) | ||
| MUC-1 | ||||||
| Negative | 69 (12.9) | 2 (2.6) | 0.020 (7.834) | 4 (5.6) | 4 (3.1) | 0.581 (0.581) |
| Moderate | 243 (45.3) | 43 (56.6) | 39 (54.9) | 66 (52.0) | ||
| Strong | 224 (41.8) | 31 (40.8) | 28 (39.4) | 57 (44.9) | ||
| BRCA1 | ||||||
| Negative | 317 (61.0) | 59 (77.6) | 0.005 (7.913) | 48 (72.7) | 85 (69.1) | 0.603 (0.270) |
| Positive | 203 (39.0) | 17 (22.4) | 18 (27.3) | 38 (30.9) | ||
| p53 | ||||||
| Negative | 435 (71.7) | 46 (48.9) | <0.001 (19.524) | 27 (36.0) | 45 (31.5) | 0.499 (0.457) |
| Positive | 172 (28.3) | 48 (51.1) | 48 (64.0) | 98 (68.5) | ||
| PTEN | ||||||
| Weak | 79 (22.8) | 3 (5.5) | 0.006 (10.092) | 0 (0.0) | 5 (5.7) | 0.265 (2.653) |
| Moderate | 130 (37.5) | 21 (38.2) | 21 (53.8) | 40 (45.5) | ||
| Strong | 138 (39.8) | 31 (56.4) | 18 (46.2) | 43 (48.9) | ||
| ER | ||||||
| Negative | 169 (28.3) | 56 (60.2) | <0.001 (37.424) | 23 (31.1) | 91 (62.8) | <0.001 (19.699) |
| Positive | 429 (71.7) | 37 (39.8) | 51 (68.9) | 54 (37.2) | ||
| PgR | ||||||
| Negative | 264 (44.2) | 65 (70.7) | <0.001 (22.321) | 36 (48.6) | 100 (71.4) | 0.001 (10.845) |
| Positive | 333 (55.8) | 27 (29.3) | 38 (51.4) | 40 (28.6) | ||
Bold values indicate significant values (p < 0.005)