Table 4. Haplotypes With Odds Ratios a, b.
| Haplotype | Frequency, % | Responders, % | Non-responders, % | OR (95% CI) | P Value |
|---|---|---|---|---|---|
| AAATTGCCCATCATG | 58.3 | 66.0 | 44.7 | 2.37 (1.34-4.20) | 0.0028 |
| TCGCCAATGATATGA | 14.0 | 12.8 | 17.9 | 0.68 (0.31-1.48) | 0.3286 |
| AAATTGCCCATAATA | 9.60 | 7.40 | 14.0 | 0.46 (0.18-1.2) | 0.106 |
| TCGCTAATCGCATTG | 8.00 | 4.20 | 12.5 | 0.28 (0.09-0.89) | 0.022 |
| TAGCCAATGGTATGA | 5.30 | 3.20 | 7.10 | 0.41 (0.10-1.64) | 0.194 |
| AAATTGCTCATAATA | 2.00 | 3.20 | 1.90 | 1.52 (0.25-9.27) | 0.650 |
a The odds ratio has been calculated as carrying of haplotype vs. not carrying the haplotype.
b The frequency of six haplotypes in responders and non-responders for a haplotype block covering 13 Kb IFN-λ. The SNP order is RS35790907, RS12972991, RS12980275, RS12982533, RS8105790, RS688187, RS4803217, RS12979860, RS4803221, RS1549928, RS10853727, RS8109886, RS8113007, RS8099917 and RS7248668.