Appendix 5. Prediction of Response to Therapy With Homozygous Responder IFN-λ Region SNPs a.
| SNP | Sensitivity, % (95% CI) | Specificity, % (95%CI) | Prevalence, % (95%CI) | PPV, % (95%CI) | NPV, % (95%CI) |
|---|---|---|---|---|---|
| RS955155 | 51.39 (42.92-59.79) | 53.57 (39.75-67.01) | 72.00 (65.23-78.10) | 74.00 (64.27-82.26) | 30.00 (21.24-39.98) |
| RS12972991 | 59.35 (50.12-68.11) | 64.94 (53.21-75.46) | 61.50 (54.38-68.28) | 73.00 (63.20-81.39) | 50.00 (39.83-60.17) |
| RS8105790 | 57.14 (48.28-65.68) | 64.18 (51.53-75.53) | 66.50 (59.50-73.00) | 76.00 (66.43-83.97) | 43.00 (33.14-53.29) |
| RS688187 | 52.48 (43.91-60.95) | 55.93 (42.40-68.84) | 70.50 (63.66-76.72) | 74.00 (64.27-82.26) | 33.00 (23.92-82.26) |
| RS4803217 | 52.48 (43.91-60.95) | 55.93 (42.40-68.84) | 70.50 (63.66-76.72) | 74.00 (64.27-82.26) | 33.00 (23.92-82.26) |
| RS12979860 | 56.92 (47.95-65.57) | 62.86 (50.48-74.11) | 65 (57.95-71.59) | 74.00 (64.27-82.26) | 44.00 (34.08-54.28) |
| RS4803221 | 51.23 (42.80-60.04) | 53.23 (40.12- 66.01) | 69.00 (62.09-75.33) | 71.00 (61.07-79.64) | 33.00 (23.92-43.12) |
| RS8109886 | 60.09 (52.55-68.92) | 79.63 (66.47-89.35) | 73.00 (66.28-79.02) | 89.00 (81.17-94.37) | 43.00 (33.14-53.29) |
| RS8113007 | 52.48 (43.91-60.95) | 55.93 (42.40-68.84) | 70.05 (63.66-76.72) | 74.00 (64.27-82.26) | 33.00 (23.92-43.12) |
| RS8099917 | 42.01 (34.47-49.83) | 6.45 (0.98-21.26) | 84.50 (78.73-89.22) | 71.00 (61.07-79.64) | 2.00 (0.30-7.05) |
| RS7248668 | 42.01 (34.47-49.83) | 6.45 (0.98-21.26) | 84.50 (78.73-89.22) | 71.00 (61.07-79.64) | 2.00 (0.30-7.05) |
| RS11671087 | 59.35 (50.12-68.11) | 64.94 (53.21-75.46) | 61.50 (54.38-68.28) | 73.00 (63.20-81.39) | 50.00 (39.20-81.39) |
| RS11665818 | 62.30 (53.07-70.91) | 69.23 (57.76-79.19) | 61.00 (53.87-67.80) | 76.00 (66.43-83.97) | 54.00 (43.74-64.01) |
a Abbreviations: 95% CI, 95% confidence interval; PPV, Positive predictive value; NPV, Negative predictive value