Figure 3.

Follicle density by diagnosis: comparing cancerous and precancerous lesions. Patients with a cancerous ovarian lesion, either a borderline or an ovarian cancer, had significantly fewer total follicles per section with significantly decreased follicle density at all stages compared to controls with physiologic findings (*). Patients undergoing risk-reducing oophorectomy had statistically fewer follicles per section compared to those with physiologic findings (**). This is consistent with the finding that patients with the BRCA mutation may have decreased ovarian reserve. In addition, ovarian cancer and borderline lesions had significantly fewer follicles compared to women undergoing risk-reducing surgery (**).