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. Author manuscript; available in PMC: 2014 Apr 12.
Published in final edited form as: Chem Biol. 2009 Apr 24;16(4):432–441. doi: 10.1016/j.chembiol.2009.02.010

Figure 3. Twenty-Eight Compounds Inhibit VEGF-A-Induced HUVEC Sprouting Angiogenesis.

Figure 3

VEGF-A-driven HUVEC angiogenesis was quantified as the average cumulative sprout length (black bars). The VEGF-A-driven sprouting was set to 100%, and the basal sprouting in the absence of VEGF-A was set to 0%. The red line is a reference line for the basal HUVEC sprouting. Scattering of clustered NHDFs in collagen gels in the presence of basal medium was set to 100% (gray bars). Twenty-eight compounds from the LOPAC library inhibited sprouting at > 50% (black bars) and NHDF scattering at < 50% (gray bars).