Figure 1.

Transcription factor-based cellular reprogramming. (A) Modern experimental techniques like DNA chips, expression arrays and next generation sequencer (Shown in the arrow) facilitate us to gain insight into the human genome and identify novel genes/factors conferring to diseases and/or cell fate modulation (B) Enforced transcriptional activation of defined factors reprogram human somatic fibroblasts into different cell types like pluripotent stem cells [8], cardiac progenitors [9] and hepatocytes [10].