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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: JACC Heart Fail. 2014 Apr;2(2):113–122. doi: 10.1016/j.jchf.2013.11.004

Figure 4. Assessment of LV fibrosis by whole-field digital microscopy and quantitative analysis in SAB-stained left ventricular (LV) sections.

Figure 4

Representative examples of SAB-stained LV sections from HFpEF patients with mild (<5%), moderate (5–10%) and severe (>15%) myocardial fibrosis (ratio of total fibrosis area (deep red) to total tissue area (yellow)) are shown (top panels), along with the corresponding definition of fibrosis (magenta) and myocardial tissue (yellow) by the Definiens® analysis program (bottom panels). Details of the custom analysis algorithm are provided in the online supplement.