. Author manuscript; available in PMC: 2015 Apr 1.

Published in final edited form as: JACC Heart Fail. 2014 Apr;2(2):113–122. doi: 10.1016/j.jchf.2013.11.004

Table 3. TTR amyloid deposition is associated with more LV fibrosis and lower heart weight after adjustment for age and presence of HFpEF.

The change in percent fibrosis or heart weight (parameter estimate and standard error (SE)) associated with each covariate and significance of the association adjusting for the other covariates in the model are shown.

	Regression coefficient	SE	p value
Percent Fibrosis (WFDM)

Age at death (per 10 yrs)	0.5%	0.3%	0.09
HFpEF (vs Control)	2.1%	0.4%	<0.001
wtTTR present (vs absent)	2.0%	0.7%	0.005

Percent Expected Heart Weight

HFpEF (vs Control)	32.2%	2.5%	<0.001
wtTTR present (vs absent)	−8.2%	4.0%	0.04

Abbreviations: SE, standard error; WFDM, whole-field digital microscopy