Table 4.
Characteristics of HFpEF patients without or with wtTTR amyloid
| wtTTR Absent | wtTTR Present |
p value | |
|---|---|---|---|
| n | 88 | 18 | |
| Male | 43% | 43% | 0.98 |
| Age at heart failure event, years | 72±13 | 86±7 | <0.001 |
| Age at death, years | 74±12 | 89±8 | <0.001 |
| Hypertension | 78% | 78% | 0.95 |
| Diabetes mellitus | 44% | 33% | 0.39 |
| Coronary artery disease | 62% | 61% | 0.94 |
| Ejection fraction at heart failure event, % | 59±9 | 59±9 | 1.0 |
| Autopsy Findings | |||
| Heart weight at autopsy, g | 557±164 | 470±140 | 0.04 |
| Percent expected heart weight | 182±53 | 152±28 | 0.02 |
| Gross left ventricular hypertrophy | 68% | 67% | 0.90 |
| Gross right ventricular hypertrophy | 50% | 33% | 0.20 |
| Gross infarct (old) | 44% | 39% | 0.67 |
| Gross fibrosis | 19% | 11% | 0.41 |
| Gross infarct (new) | 11% | 11% | 0.98 |
| Left ventricular dilatation | 39% | 39% | 0.98 |
| Right ventricular dilatation | 49% | 44% | 0.73 |
| Atrial dilatation | 55% | 56% | 0.94 |
| Microscopic fibrosis | 53% | 72% | 0.14 |
| Microscopic hypertrophy | 27% | 44% | 0.15 |
| Microscopic infarct | 14% | 33% | 0.04 |
| Coronary disease score | 11±4 | 11±4 | 0.66 |
| % Fibrosis (WFDM) | 12±7 | 17±14 | 0.02 |
| ECG findings closest to Death | |||
| n | 66 | 12 | |
| Low QRS voltage (limb) | 5% | 8% | 0.58 |
| Low QRS voltage (precordial) | 3% | 8% | 0.38 |