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. Author manuscript; available in PMC: 2014 Apr 12.
Published in final edited form as: Gynecol Oncol. 2008 May 29;110(2):237–245. doi: 10.1016/j.ygyno.2008.04.013

Figure 6. S1P mediated invasion pathways.

Figure 6

Low concentration S1P enhances invasion through activation of uPA and MMP2 via Gi and Rac. Low concentration S1P also leads to Gi dependent clustering of N-cadherin. Baseline invasion of cells in the absence of S1P is inhibited through a Gi pathway. High concentration S1P enhances this inhibition.