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. 2014 Feb 3;16(5):637–651. doi: 10.1093/neuonc/not300

Fig. 11.

Fig. 11.

Inhibition of tumor growth and angiogenesis by LAMB1 knockdown in glioma xenografts. Tumors induced in immunocompromised nu/nu mice were injected with siRNA-LAMB1-1608 or siRNA-NC (negative control) for 3 weeks. (A) Growth of U87 or U251 xenografts was assessed at the beginning and end of the experiment. (B) Volume of U87 or U251 xenografts was measured every 3 to 4 days. (C) Microvessel density in U251 xenografts injected with siRNA-LAMB1-1608 or siRNA-NC, as determined by immunohistochemical staining for the vascular endothelial cell marker CD31. The number of vessels per field (200×) was counted. Data are shown as mean ± SD. *P < .05; **P < .01. Scale bar = 200 μm.