Table 1.
Summary of study characteristics, radiation dose, survival outcomes, and complications in selected studies of atypical meningioma
| Study | Period | Total AM, n | Received RT, n | Malignancy Definition | Proportion of All Meningiomas | Median Follow-up | Treatment Modality | Dose | Progression-free Survival | Overall Survival | Complications |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Milosevic et al27 | 1966–1990 | 18 | 18 | WHO 1979 | 68.6% (grade II/III) | 40 mo (7–114) | Surgery + RT (n = 17) | 50 Gy (40–60) | n/a | 51% at 5 y | 3.39% related to RT |
| Pasquier et al13 | 1971–2005 | 30 | n/a | WHO 2000 | n/a | 4.1 y | Surgery + RT | 54 Gy (40–66) | 62% at 5 y | 67.5% at 5 y | 12.6% related to RT |
| Hug et al7 | 1973–1995 | 15 | 15 | WHO 1993 | n/a | 28 mo (7–155) | Surgery + photon RT (n = 4) vs surgery + photon + proton RT (n = 11) | 62 Gy (50–68) | 38% at 5 y | 89% at 5 y (90% for >60 Gy vs 0% for <60 Gy) | 6.67% related to RT |
| Mahmood et al26, a | 1976–1990 | 22 | 3 | WHO 1993 | 8.0% (grade II/III) | 38 mo (3–186) | Surgery (n = 14), surgery + RT (n = 6) | 50–62 Gy | 48% at 5 y; 33% at 10 y | 58.33% at 5 y; 41.67% at 10 y | n/a |
| Goyal et al25 | 1979–1995 | 22 | 8 | WHO 1979 | 6.7% (grade II) | 5.5 y (1.5–14.8) | Surgery (n = 14), surgery + RT (n = 8) | 54 Gy (35–59.4) | Surgery: 70% at 5 y; surgery + RT: 80% at 5 y | Surgery: 81% at 5 y; surgery + RT: 100% at 5 y | n/a |
| Kano et al31 | 1997–2002 | 10 | 10 | WHO 2000 | n/a | 44 mo (6–84) | Surgery + SRS | 18 Gy (12–20) | 48.3% at 5 ya | 80.8% at 5 ya | 16.7% related to SRSa |
| Yang et al29 | 1986–2004 | 40 | 23 | WHO 2000 | 7.2% (grade II/III) | 63.6 mo (0.6–154.5) | Surgery, surgery + RT | n/a | 87.1% at 10 y | 89% at 10 y | n/a |
| Aghi et al15 | 1993–2004 | 108 | 8 | WHO 2000 | n/a | 39 mo (1–168) | Surgery (n = 100), surgery + RT (n = 8) | 60.2 Gy (59.4–61.2) | Surgery + RT: 100% at 5 y; surgery: 44% at 5 y | n/a | 12.5% related to RT |
| Boskos et al30 | 1999–2006 | 19 | 19 | n/a | n/ab | 48 mo(1–87) | Surgery + RT | 65 CGE (proton = 34.1 CGE; photon = 31 Gy) | 46.7% at 5 ya | 53.2% at 5 ya | 16.7% related to RTa |
| Mair et al16 | 2001–2010 | 114 | 30 | WHO 2000 | n/a | n/a | Surgery (n = 83), surgery + RT (n = 31) | 51.8 Gy | Surgery: 40%; surgery + RT: 60% | n/a | n/a |
Abbreviation: CGE, cobalt gray equivalent.
aIn this study, atypical and malignant meningiomas were aggregated into the same group. Boskos et al30 and Kano et al31 reported PFS, OS, and the complication rate for their aggregated group of atypical and malignant meningiomas, rather than separately.
bBoskos et al30 cited the WHO 1993 classification scheme but did not explicitly report which scheme was used.