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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Curr Pharm Des. 2013 Feb;19(29):5250–5269. doi: 10.2174/13816128113199990344

Figure 2. The fate of excess fatty acids is linked to the severity of nonalcoholic fatty liver disease.

Figure 2

Increased hepatic inflow of fatty acids due to peripheral insulin resistance is associated in some patients with lipotoxic injury, while in other to limited damage. Experimental evidence indicates that accumulation of triglycerides may represent a protective mechanism to limit the toxic action of fatty acids and other lipotoxic products. In the presence of lipotoxicity, steatohepatitis develops possibly leading to end stage liver disease and its complications.