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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Curr Pharm Des. 2013 Feb;19(29):5250–5269. doi: 10.2174/13816128113199990344

Figure 4. Dietary factors influence the development of steatohepatitis.

Figure 4

Saturated fatty acids, particularly palmitic acid, are highly lipotoxic and may lead to apoptotic cell death. In contrast, n-3 PUFA have a protective effect on steatosis. Free cholesterol targets the mitochondria, and contributes to lipotoxicity and apoptosis. Fructose favors steatosis and contributes to injury, inflammation and fibrogenesis increasing the availability of lipopolysaccharide (LPS), increasing the levels of advanced glycation end-products (AGE), increasing iron and depleting copper.