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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Eur Heart J. 2012 Jul 26;34(32):2566–2574. doi: 10.1093/eurheartj/ehs227

Figure 1. PPARα-activation with GFT505 in-vivo in mice and GFT505 and GW7647 ex-vivo in human jejunal biopsies increases the expression of genes involved in HDL production.

Figure 1

Q-PCR analysis of ABCA1 (A, C, E) and apoAI (B, D, F) was performed on RNA isolated from scrapped intestinal mucosa (A, B, C, D) of GFT505 (30mpk) or FF (200mpk)-treated apoE2-KI mice for 14d and from human jejunal biopsies (E, F) treated with GW7647 (600nM) and GFT505 (1μM) for 18h. In vivo values are expressed as means ± SEM and ex vivo values as means ± SD. t test; *, P<0.05; ***,P<0.001 Vehicle vs treatment).