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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Eur Heart J. 2012 Jul 26;34(32):2566–2574. doi: 10.1093/eurheartj/ehs227

Figure 2. GW7647 increases the production of HDL by Caco-2/TC7.

Figure 2

Caco-2/TC7 (non-infected, ShControl- or ShPPARα-infected) were treated with GW7647 (600nM) for 48h (Q-PCR and ELISA analysis) or 72h (cholesterol efflux assay).

(A) Number of HDL secreted by non-infected Caco-2/TC7 per equivalent volume. (B) ELISA analysis of apoAI in the HDL fraction (representative of 3 independent experiments, values are expressed as means ± SEM). (C) Cholesterol-loaded primary human macrophages were incubated with HDL secreted by Caco-2/TC7 (representative of 2 independent experiments, values are expressed as means ± SEM). (D) Q-PCR analysis of ABCA1. Values are expressed as means ± SD. t-test; *P<.05; **P<.01; ***P<.001 Vehicle vs treatment; #P<.05 treated ShControl- vs treated-ShPPARα-infected cells.