Cross-sections through the olfactory bulbs of double transgenic mice expressing
TrpM5-driven GFP (GFP+, green) and NT-3-driven β-galactosidase
(βgal+, red). (A1) Labeled axons for both reporter genes
terminate in glomeruli throughout the glomerular layer of the MOB. Arrows
indicate a few strongly labeled for the two reporters: GFP+ or
βgal+; Dbl − indicates a double-labeled glomerulus. (A2)
Plot of each mapped glomerulus from the bulb cross-section in (A1). The origin
line in the center of the plot indicates the counter-clockwise cylindrical
coordinates of each glomerulus, where 0, 90, 180, and 270° indicate
dorsal, lateral, ventral, and medial, respectively. The color in each glomerulus
is determined by an RGB triplet in which the red and green values correspond to
the mean red and green intensities of the pixels contained within the glomerular
profile, and the blue value is set to zero. (B and C) GFP+
and βgal+ glomeruli are shown in the ventral MOB of a single
female mouse and (D and E) a single male mouse. Immunolabeling was
performed with antibodies against GFP (green) and βgal (red), reporter
proteins for TrpM5 and NT-3 expression, respectively; DAPI counterstain, blue
A–E. Scale bar = 100μm.