Table 2.

Association between rs13273442 genotype and dependence for multiple substances in each of the individual sub-samples together with meta-analysis within ancestry group and across all strata (Fixed effects meta-analysis model)

			Nicotine			Alcohol			Cocaine			Marijuana
Ancestry	Study	N	OR	(CI)	p	OR	(CI)	p	OR	(CI)	p	OR	(CI)	p
EA	COGEND	1899	0.79	(0.65–0.96)	0.02	1.03	(0.82–1.29)	0.82	1.06	(0.70–1.62)	0.77	0.79	(0.55–1.12)	0.18
EA	COGA	974	0.56	(0.39–0.80)	1.4e-3	1.31	(0.88–1.96)	0.18	1.18	(0.78–1.79)	0.44	0.85	(0.58–1.26)	0.42
EA	FSCD	558	0.99	(0.59–1.72)	0.99	0.82	(0.49–1.37)	0.45	1.45	(0.74–2.84)	0.27	1.08	(0.66–1.76)	0.77
EA	Meta-analysis	3431	0.75	(0.64–0.88)	5.8e-4	1.05	(0.87–1.27)	0.59	1.17	(0.89–1.53)	0.26	0.87	(0.69–1.09)	0.22
AA	COGEND	676	0.97	(0.71–1.32)	0.84	1.19	(0.80–1.76)	0.39	0.93	(0.51–1.68)	0.80	1.31	(0.86–1.97)	0.20
AA	COGA	373	0.58	(0.36–0.96)	0.03	1.66	(0.86–3.18)	0.13	1.19	(0.64–2.19)	0.58	1.00	(0.61–1.65)	0.99
AA	FSCD	612	0.69	(0.45–1.08)	0.11	0.92	(0.61–1.37)	0.67	1.21	(0.62–2.38)	0.58	1.19	(0.78–1.80)	0.42
AA	Meta-analysis	1661	0.80	(0.64–1.00)	0.05	1.12	(0.87–1.45)	0.37	1.09	(0.76–1.57)	0.64	1.18	(0.91–1.52)	0.20
EA+AA	Meta-analysis	5092	0.77	(0.67–0.88)	8.6e-5	1.08	(0.93–1.25)	0.34	1.14	(0.92–1.42)	0.24	1.00	(0.84–1.18)	0.97

COGEND: Collaborative Genetic Study of Nicotine Dependence

COGA: Collaborative Study on the Genetics of Alcoholism

FSCD: Family Study of Cocaine Dependence

EA: European ancestry

AA: African American

Results for dependence variables from analyses predicting genotypes using all substance dependencies, sex, and age quartile as predictors

MODEL: genotype = sex + age quartile + nicotine dependence + alcohol dependence + marijuana dependence + cocaine dependence + smoking exposure (Y/N at least 100 cigs/lifetime) + ever drank alcohol (Y/N) + ever used cocaine (Y/N) + ever smoked marijuana (Y/N)

Minimum p-value range for tests of heterogeneity: (0.14 – 0.95).