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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: Curr Opin Struct Biol. 2014 Feb 4;0:115–124. doi: 10.1016/j.sbi.2014.01.008

Figure 1. Subunit architecture and model of the catalytic core in the Tetrahymena EM structure.

Figure 1

(a) The 25 Å EM model of the Tetrahymena telomerase holoenzyme with locations and known boundaries of subunits colored in. (b) Model of the Tetrahymena telomerase holoenzyme with the complete TERT-TER-p65 RNP catalytic core plus Teb1C (PDB ID: 3U50) modeled into the EM map. Modeled domains of TER are represented by tube and ladder and NMR structures are shown with atoms. (c) NMR solution structure of Tetrahymena TER Stem 4 (PDB ID: 2FEY) [80] and Loop 4 (PDB ID: 2M21) and crystal structure of Tetrahymena p65 xRRM bound to Stem 4 (PDB ID: 4ERD) with Loop 4 modeled.