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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: Curr Opin Struct Biol. 2014 Feb 4;0:115–124. doi: 10.1016/j.sbi.2014.01.008

Figure 3. EM structures of Tetrahymena telomerase holoenzyme and human telomerase dimer.

Figure 3

(a) EM structure of bilobal human telomerase dimer (EMDB: 2310). (b) and (c) EM structures of the “open” (EMDB: 2311) monomer of human telomerase dimer b and the Tetrahymena telomerase holoenzyme (EMDB: 5804) (c) with the TRBD, RT, and CTE of TERT and the template of TER modeled in. Proposed region of dsRNA in b is indicated with oval outline. The structures from Tetrahymena and human are shown with TERT (PDB ID: 3KYL) in the same orientation for comparison. The arrows point to the putative binding site of TER CR4/5 in human telomerase b and the modeled binding site of TER Stem 4 in the Tetrahymena telomerase holoenzyme c.