Figure 4. Solution structures of telomerase pseudoknots.

(a) Secondary structure schematic of human TER with t/PK, CR4/5, and the H/ACA scaRNA motifs boxed. (b) Secondary structure schematic and NMR solution structure of the human P2b-P3 pseudoknot (left) (PDB ID: 1YMO) and K. lactis (right) (PDB ID: 2M8K). (c) Proposed pseudoknot secondary structure from (top) S. cerevisiae (budding yeast) [25], (middle) S. purpuratus (purple sea urchin) [78], and A. oryzae (filamentous fungi) [79].