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. 2014 Apr 9;15:122. doi: 10.1186/1471-2474-15-122

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Copyright © 2014 Lloyd et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Osteocyte size and circularity. Quantification of the relative size and circularity of (A, B) lacunae containing viable osteocytes and (C, D) empty lacunae in cortical bone from wild-type (WT) and Cx43 conditional knockout (cKO) mice following three weeks of normal loading conditions (Control) or mechanical unloading via hindlimb suspension (Suspended). Lacunae were quantified within a 2400 μm linear region of the mid-diaphysis of the femur. Mean ± SE. * indicates a significant difference (p < 0.05) between Control and Suspended within a genotype, while † indicates a significant difference (p < 0.05) between WT and cKO within a loading condition. n = 5/group.