Table 3.
Effects of dietary supplementation with SAqFSC-P, PAqFSC-P, or bicyclol on body weight gain and food/drug intake in normal and hypercholesterolemic mice
| Groups | Drug concentration (%, w/w) |
Body weight gain (g) |
Food intake (g/kg/day) | Drug intake (g/kg/day) | |
|---|---|---|---|---|---|
| D 1 → D 5 | D 5 → D 10 | ||||
|
Normal mice
|
|
|
|
|
|
| Control ND |
- |
7.41 ± 0.29 |
4.46 ± 0.22 |
156.4 |
- |
| SAqFSC-P/ND |
1 |
7.52 ± 0.07 |
3.41 ± 0.18a |
142.2 |
1.42 |
| |
9 |
7.19 ± 0.16 |
3.53 ± 0.27a |
157.5 |
14.18 |
| PAqFSC-P/ND |
1 |
7.42 ± 0.17 |
3.99 ± 0.36 |
143.7 |
1.44 |
| |
9 |
7.49 ± 0.35 |
4.54 ± 0.26 |
151.4 |
13.63 |
| Bicyclol/ND |
0.025 |
7.41 ± 0.20 |
3.70 ± 0.26a |
158.3 |
0.04 |
|
Hypercholesterolemic mice
|
|
|
|
|
|
| Control ND |
- |
10.42 ± 0.25 |
3.04 ± 0.14 |
162.7 |
- |
| Control HCBD |
- |
9.76 ± 0.16a |
2.81 ± 0.12 |
151.0 |
- |
| SAqFSC-P/HCBD |
1 |
9.71 ± 0.29 |
3.02 ± 0.10 |
151.4 |
1.51 |
| |
3 |
9.36 ± 0.20 |
2.98 ± 0.19 |
150.0 |
4.50 |
| PAqFSC-P/HCBD |
1 |
10.02 ± 0.28 |
2.78 ± 0.11 |
150.5 |
1.51 |
| |
3 |
9.66 ± 0.15 |
3.11 ± 0.16 |
157.5 |
4.72 |
| Bicyclol/HCBD | 0.025 | 10.36 ± 0.23 | 2.72 ± 0.13 | 152.5 | 0.04 |
Experimental details were described in Figure 1. The dosages (g/kg/day, based on crude herbal material) were determined with respect to the amount of ingested diet (g/day/kg) and drug concentration in the diet. Values given are the means ± S.E.M., with n = 10. aP < 0.05 vs. control ND, using a one-way ANOVA followed by Dunnett’s multiple comparisons test or post-hoc analysis.