Table 1.

Summary of published cases of severe and complicated P. ovale infection

Reference	Patient age	Gender	Medical history	Travel history	Prophylaxis	Time to presentation	Parasitaemia	WHO or other severity criteria	Treatment	Outcome
This case report	42 yr	Male	None	Kalia, Guinea: 6 months ago Mozambique: 1 month ago	None	1-6 months	1.4%	Jaundice, respiratory distress, hypotension, incipient bleeding	IV quinine, 14 days primaquine	Recovered
Lee et al. [16]	31 yr	Female	None	Ghana	Mefloquine	10 months	0.1%	ARDS	Chloroquine, 14 days primaquine	Recovered
Rojo Marcos et al. [17]	43 yr	Male	Hypertensive, diabetic	Nigeria	None	N/S	6,000/μL	ARDS	Chloroquine, 14 days primaquine	Recovered
Haydoura et al. [18]	46 yr	Female	Methylenetetrahydrofolate reductase mutation with secondary portal vein thrombosis	Acquired by transfusion	N/A	1 month following transfusion	1.11%	ARDS	IV quinine and doxycycline, 14 days primaquine	Recovered
Roze et al. [19]	24 yr	Male	Tuberous sclerosis	Chad, Ivory Coast	Doxycycline	1 year	0.1%	ARDS	Chloroquine then changed to quinine	Recovered
Lau et al. [20]	59 yr	Male	None	Victoria Island, Nigeria	Mefloquine	6 months	0.18%	ARDS, acute renal failure, metabolic acidosis	Chloroquine plus primaquine, changed to quinine, then artesunate	Demised
Hashimi et al. [21]	31 yr	Male	Previous pulmonary tuberculosis (20 years ago)	Democratic Republic of Congo	N/S	7 months	0.2%	ARDS	IV quinine	Demised
Facer et al. [23]	51 yr	Female	N/S	Ghana	None	12 days	1.8%	Splenic rupture	None	Demised
Patel et al. [24]	42 yr	Male	N/S	South and Central Africa	Hydroxychloroquine, discontinued during travel	18 months	N/S	Splenic rupture	Chloroquine and primaquine	Recovered
Cinquetti et al. [25]	34 yr	Male	None	Senegal 2002, Ivory Coast 2004	Doxycycline	2-4 years	0.001%	Splenic infarction	IV quinine	Recovered

N/S: Not stated; N/A: not applicable; ARDS: Acute respiratory distress syndrome.