Table 3.

Summary table of included reviews - hypertension

Citation	NHMRC level of evidence	Included studies	Total participants	Participants condition	Inclusion criteria	Intervention	Outcomes	Results	Conclusion
Agarwal et al. [17]	I	37	9446	Hypertension	• Published between 1966-2010	Home BP monitoring compared to a control group.	• BP - diastolic, systolic and mean arterial • Medication use	Compared with clinic based measurements, home based BP monitoring; • Improved systolic BP (SMD −2.63 mmHg, 95% CI −4.24 to −1.02; 22 studies) • Improved diastolic BP (SMD - 1.68 mmHg, 95% CI −2.58 to −0.79 mmHg; 22 studies) • Improved mean arterial pressure (SMD −4.0 mmHg, 95% CI −6.22 to −1.79 mmHg; 3 studies) • Reduced medication use (RR 2.02, 95% CI 1.32 to 3.11; 10 studies) • Reduced therapeutic inertia (RR 0.82, 95% CI 0.68 to 0.99; 15 studies) • Led to no greater increase in medication (RR 0.94, 95% CI 0.75 to 1.19; 12 studies)	• Compared with clinic BP monitoring alone, home BP monitoring had the potential to overcome therapeutic inertia [no change in medication]. • Lead to a small but significant reduction in systolic and diastolic BP. • Hypertension management with home BP monitoring can be enhanced when used with telemonitoring.
Neubeck et al. [18]	I	11	3145	Coronary Heart Disease	• English language • Published between 1990-2008	Intervention involved home monitoring with 50% patient provider contact for risk factor modification and advice/counselling for CHD patients	• All-cause mortality • Modifiable risk factors including cholesterol (and associated measures), BP, BMI, Smoking Status, Physical Activity • Quality of life • Cost	Compared to the control group the evidence suggests that the intervention group had; • Reduced total cholesterol (WMD 0.37 mmol/L, 95% CI: 0.19 to 0.56, 9 studies) • Reduced low-density lipoprotein cholesterol (WMD 0.41 mmol/L, 95% CI: 0.36 to 0.56, 4 studies) • Reduced systolic blood pressure (WMD 4.69 mmHg, 95% CI 2.91 to 6.47, 7 studies) • Reduced risk of smoking (RR 0.83, 95% CI: 0.70 to 0.99, 7 studies)	• Telemonitoring interventions provided effective risk factor reduction and secondary prevention in patients with CHD. • Telemonitoring could increase the uptake of formal secondary prevention by those who do not access cardiac rehabilitation, and narrow the current gap between evidence and practice.
						• Telephone based telemonitoring – 9 studies
						• Internet based telemonitoring – 2 studies
Omboni et al. [19]	I	12	5044	Hypertension	• English language • Published between inception - 2010	Home BP monitoring with data being automatically transferred compared to control group.	• Change in BP (diastolic, systolic and normalisation) • Medication	Compared to controls the overall effect of home BP monitoring was; • Improved office systolic BP (5.64 mm Hg, 95% CI: 7.92 to 3.36 mm Hg, 11 studies) • Improved office diastolic BP (2.78 mm Hg, 95% CI: 3.93 to 1.62 mm Hg, 11studies) • Improved ambulatory systolic BP (2.28 mm Hg, 95% CI: 4.32 to 0.24 mm Hg; 3 studies) • Improvement in BP control (RR 1.31, 95% CI: 1.06 1.62, 5 studies)	• Home blood pressure telemonitoring may represent a useful tool to improve blood pressure control but well-designed large-scale trials are still needed to demonstrate its clinical usefulness.
Verberk et al. [20]	I	9	2662	Hypertension	• English language • No restriction on dates reported	Home BP transmitted via telephone, internet, modem or mail.	• BP - diastolic, systolic • Medication	• Increased use of antihypertensive medications (WMD +0.22, 95% CI: +0.02, +0.43, 5 studies) Compared with usual care, home based BP monitoring; • Reduced systolic BP (5.19 mmHg, 95% CI 2.31 to 8.07; 9 studies) • Reduced diastolic BP (2.11 mmHg, 95% CI 0.52 to 3.69; 9 studies) • There was no significant difference between groups in the number of patients that reached their target blood pressure (3 studies)	• Telecare led to a greater decrease in systolic and diastolic blood pressure than usual care. For systolic blood pressure, this decrease was greater in trials without treatment modification.