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. Author manuscript; available in PMC: 2014 Oct 11.
Published in final edited form as: Adv Synth Catal. 2013 Oct 7;355(14-15):3037–3057. doi: 10.1002/adsc.201300640

Table 1.

Final Optimization of the Asymmetric, Conjugate Addition of BBA.

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entry concentration temperature equiv of BBA yield (%) enantiomeric ratio[a]
1 0.1 M rt 2 87 91:9
2 0.25 M rt 2 82 94:6
3 0.5 M rt 2 90 93:7
4 0.5 M rt 1.5 80 92:8
5 0.5 M rt 1.2 67 92:8
6 0.5 M 0 °C 2 77 93:7
[a]

Enantiomeric excess determined by oxidation of 2a to 6 followed by SFC analysis of 6