Table 6.

Cross-Coupling of 2a with Heteroaryl Chlorides and Diverse Aryl Electrophiles.

entry	product		yield (%)	enantiomeric ratio
1	12a	X = Cl	56 (52)[a]	91:9 (95:5)[a]
2	12b	X = Cl	60	94:6
3	12c	X = Cl	53	95:5
4	12d	X = Cl	58	92:8
5	12e	X = Cl	43	92:8
6	12f	X = Cl	85	92:8
		X = Br	68	95:5
		X = l	(−)[b]	(−)
		X = OMs	73	92:8
		X = OTf	78	90:10
		X = OTs	(−)[b]	(−)
		X = OSO2NMe2	(−)[b]	(−)

^[a]Reaction performed on a 3.33 mmol scale with 2.5 mol % XPhos-Pd-G2.

^[b]No product observed.