Figure 3.
SAHA reduces infarct size and preserves systolic function in a rabbit I/R model. a. Representative TTC staining in three treatment groups after I/R (30 min/24 hour). White: Infarct, Red: AAR, Blue: Remote. b. SAHA reduced IF/AAR as determined by TTC staining (n = 7, p<0.001). c. There were no significant differences in AAR among groups. d. SAHA reduced IF normalized by left ventricle weight (LV) (n = 7, p<0.05). e. Representative M-mode echocardiograms. f. SAHA treatment partially preserved echocardiography-determined %FS after I/R (30 min/24 hour) (n=7, p<0.001). g. The reduction in %FS after I/R was significantly lower in the SAHA treatment group (n=7, p<0.001).