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. Author manuscript; available in PMC: 2015 Mar 11.
Published in final edited form as: Circulation. 2014 Jan 6;129(10):1139–1151. doi: 10.1161/CIRCULATIONAHA.113.002416

Figure 7.

Figure 7

μa. Upper: LC3 Western blot. At steady state, LC3-II levels normalized to GAPDH decreased in both DMSO and SAHA groups after 2 hours of ischemia plus 2 hours of reperfusion (I2hR2h). However, after Bafilomycin A treatment, SAHA treatment induced increases in LC3II levels after simulated I/R (n=3, p<0.05). Lower: Quantification. b. LDH cell death assay. SAHA treatment (2μM) reduced cell death around 20% after sI/R (5 hour/1.5 hour) (n=3, p<0.05). Suppression of ATG7 abolished SAHA's cardioprotective effects after sI/R (n=3, p<0.05).