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Comparison of plasma SAHA levels in rabbit with those of human subjects receiving IV SAHA. Measured rabbit plasma SAHA concentration parameters were compared with those from human subjects receiving IV SAHA during a phase 1 clinical trial.
| Dose level | n | Cmax (ng/mL) | AUCinf (h × ng/mL) |
|---|---|---|---|
| 300mg/m2 | 11 | 2646 ± 588 | 4285 ± 1150 |
| 300mg/kg SQ rabbit | 8 | 872 ± 106 | 5438 ± 528 |
| 600mg /m2 | 9 | 6334 ± 3086 | 11233 ± 6928 |
| 900mg/m2 | 11 | 9525 ± 1611 | 16611 ± 4533 |
