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. Author manuscript; available in PMC: 2015 Mar 11.
Published in final edited form as: Circulation. 2014 Jan 6;129(10):1139–1151. doi: 10.1161/CIRCULATIONAHA.113.002416

Table 1.

Comparison of plasma SAHA levels in rabbit with those of human subjects receiving IV SAHA. Measured rabbit plasma SAHA concentration parameters were compared with those from human subjects receiving IV SAHA during a phase 1 clinical trial.

Dose level n Cmax (ng/mL) AUCinf (h × ng/mL)
300mg/m2 11 2646 ± 588 4285 ± 1150
300mg/kg SQ rabbit 8 872 ± 106 5438 ± 528
600mg /m2 9 6334 ± 3086 11233 ± 6928
900mg/m2 11 9525 ± 1611 16611 ± 4533
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