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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Integr Biol (Camb). 2014 Feb;6(2):127–142. doi: 10.1039/c3ib40188j

Figure 3.

Figure 3

Finite element simulations of A,B) equilibrium oxygen concentrations of submerged and air-liquid interface culture configurations under normoxic conditions in which “a” indicates air, “m” indicates culture medium, “c” indicates the encapsulating collagen matrix, “p” indicates the porous membrane, and “o” indicates the primary intestinal organoid. C,D) Detailed oxygen concentrations and oxygen flux lines (white arrows) of inset areas from panel A along with similar regions under E,F) 10% and G,H) 1% ambient oxygen concentrations. I) Equilibrium oxygen concentrations and J) oxygen gradients experienced across the diameter of an encapsulated organoid within submerged and air-liquid interface culture conditions under ambient oxygen concentrations tested.