Fig. 2.

Comparison the effect of parameters on the survivability. (A) Following MCAo for 1.5 h, the mortality was too high in the animals without any treatment (○). The mortality was slightly reduced when the animals were treated with Enrofloxacin (antibiotic) and Tramadol (opioid analgesic) (●). Occlusion for 1 h with a nylon suture with #2312 and treatment with Enrofloxacin and Tramadol enhanced the survival rates up to 60% (▲). It should be noted that 7 days after the ischemic injury, animals were stabilized and no more death occurred. (B) In the brains from the MCAo animals, the infarcted area in the right hemisphere was not stainable by TTC. (C) The infarcted area was calculated and shown as the means±S.E. at least three animals per group. The difference among the groups was insignificant.