Figure 4.

Insertion sites in mammalian transporters near the extracellular gate. Alignment of the primary sequences of vSGLT, PutP, hSGLT1, and hSGLT2 showing the regions around the two insertion sites found in mammalian transporters, which are absent in the bacterial homologs. Secondary-structure elements are shown above the sequences based on the structure of vSGLT. Strictly conserved and highly conserved residues are shown in red and blue, respectively. Insertion sites 1 (A) and 2 (B) are shown as gray boxes. To see this figure in color, go online.