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. 2014 Apr 7;5:70. doi: 10.3389/fgene.2014.00070

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Copyright © 2014 Pelosi, Rocchiccioli, Cecchettini, Viglione, Puntoni, Parodi, Capobianco and Trivella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top: Histologic features of coronary lesions in a typical HF (panel A, fatty streak, H&E 2×, insets 10× and 20×) and HHF case (Panel B, atheroma, H&E 4×, inset Mallory trichrome 10×). Bottom: Coronary profiling (left anterior descending artery) of IT values of observed lesions in 11 consecutive segments of a HF case (panel A) and in 9 consecutive segments of a HHF case (panel B). Median of IT values is about one half of the mean of IT values in mild localized atherosclerotic changes of HF case (left), whilst it is equal to the mean of IT values when diffuse severe changes are present (HHF case, right).