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. 2014 Apr 7;5:63. doi: 10.3389/fphar.2014.00063

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Copyright © 2014 Nisticò, Ferraina, Marconi, Blandini, Negri, Egebjerg and Feligioni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mRNA expression level of SUMO and SUMO-related proteins in hippocampal tissues. Analyses of SUMO-1 (A), SUMO-2 (B), SUMO-3 (C), SENP1 (D), Ubc9 (E) mRNA expression in brain hippocampus of Tg2576 and WT mice at the age of 1.5 and 6 months. The mRNA expression levels, determined by real-time polymerase chain reaction (RT-PCR), were expressed in relation to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and presented as fold increase relative to WT animals. Data represent mean ± s.e.m. of 4 animals. (t-test) ^*p < 0.05 Tg2576 vs. WT.