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. 2014 Apr 7;6:59. doi: 10.3389/fnagi.2014.00059

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Copyright © 2014 Zimmerman, Sutton, Low, Fletcher, Tan, Schneider-Garces, Li, Ouyang, Maclin, Gratton and Fabiani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representations of mediation analyses. Top panel: Schematic representation of the results of the mediation analysis performed with the global gray matter CBF as the dependent variable. Middle panel: Schematic representation of the results of the mediation analysis performed with the parietal gray matter CBF as the dependent variable. Bottom panel: Schematic representation of the results of the mediation analysis performed with the parietal white matter CBF as the dependent variable. eCRF significantly mediates the effect of age on CBF in the global gray matter and parietal gray matter, but not in the parietal white matter.