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. Author manuscript; available in PMC: 2014 Apr 14.
Published in final edited form as: NMR Biomed. 2011 May 25;25(1):113–122. doi: 10.1002/nbm.1723

Figure 6.

Figure 6

Necrotic and hypoxic (pimonidazole-positive) fractional areas in AT tumors. Necrotic fraction was measured in tumors that were studied by MRSI and histology (n = 8, black triangles) and by histology alone (n = 6, gray triangles). Hypoxic fraction was determined for imaged tumors (n = 8, light gray circles). Both necrotic and hypoxic fractions increase with increasing volume. Lactate (crosses) is detected in tumors across the entire volume range, including tumors smaller than 1000 mm3, where necrotic fraction is low (below 3%). This indicates that lactate is partly produced by the non-necrotic tumor tissue.