TABLE 2.

Association between trans fat intake and stroke incidence in the REGARDS study¹

	All strokes			Ischemic strokes
	Overall	Men	Women	Overall	Men	Women
No. of cases	479	265	214	401	221	180
Person-years	109,247	48,547	60,700	109,423	48,670	60,753
Model2
1	1.17 (1.08, 1.27)3	1.20 (1.08, 1.33)	0.97 (0.83, 1.13)	1.16 (1.06, 1.27)	1.19 (1.06, 1.34)	0.96 (0.81, 1.14)
2	1.08 (0.99, 1.18)	1.14 (1.03, 1.27)	0.96 (0.82, 1.12)	1.07 (0.97, 1.18)	1.14 (1.01, 1.27)	0.95 (0.81, 1.13)
3	1.07 (0.97, 1.18)	1.14 (1.02, 1.28)	0.93 (0.79, 1.11)	1.06 (0.96, 1.18)	1.13 (1.00, 1.28)	0.93 (0.77, 1.12)

¹The REGARDS study recruited 30,239 participants; 8447 participants were excluded for missing food-frequency questionnaire data, 214 for missing data on mortality, 919 for history of stroke at baseline, and 3552 for missing data on covariates, which left 17,107 participants for the current analysis. trans Fat intake was modeled in 1-SD increments (1 SD = 2.13 g/d). REGARDS, REasons for Geographic And Racial Differences in Stroke.

²Results were obtained by using Cox regression analyses. Model 1: unadjusted; model 2: adjusted for sex, age, and smoking status; model 3: adjusted as for model 2 plus race, age × race interaction, region, alcohol use, education, waist circumference, level of physical activity, diabetes, ischemic heart disease, hypertension, baseline stroke, heart failure, kidney failure, statin use, regular aspirin use, total energy and energy-adjusted saturated fat, monounsaturated fat, polyunsaturated fat, and protein.

³HR; 95% CI in parentheses (all such values).