Table IV.

Subgroup analysis by bronchopulmonary dysplasia

Demographic and perinatal factors n = 26	No BPD n = 15	BPD n = 11	P value
Gestational age, weeks (median [IQR])	27 0/7 (3)	26 3/7 (1.6)	.26*
Birth weight, g (median [IQR])	870 (450)	880 (240)	.44*
Male, %	46.6	36.4	.60†
African-American, %	66.7	63.6	.87†
1-minute Apgar score, median (IQR)	5 (5)	4 (3)	.33*
5-minute Apgar score, median (IQR)	7 (2)	7 (2)	.61*
Cesarean delivery, %	53.3	72.7	.31†
No antenatal steroids, %	6.7	27.3	.15†
PPROM, %	40	45.5	.78†
Clinical choriamnionitis, %	26.6	18.2	.61†
Pathological chorioamnionitis, %	66.7	36.4	.12†
History of fetal distress, %	66.6	50.0	.51†
Clinical factors
SNAP score, median (IQR)	17 (7)	15 (10)	.26*
Surfactant doses, median (IQR)	2 (2)	2 (1)	.61*
Days on MV, median (IQR)	4 (26)	26 (25)	.04*‡
Days on inotropes, median (IQR)	1 (2)	2 (2)	.10*
Confirmed infection, %	0	27.3	.02†‡
PDA medically treated, %	26.7	54.5	.14†
PDA surgically treated, %	6.7	9.1	.81†
Caffeine level at 1-week, μg/mL (median [IQR])	16.5	11.4	.43*
1-week plasma cytokine concentrations, pg/mL (median [IQR])
TNF-α	29.6 (22.3)	23.8 (24.3)	.285*
IL-1β	0.005 (0.59)	1.07 (3.85)	.008*†
IL-6	10.8 (17.9)	30.7 (31.5)	.011*†
IL-10	64.3 (80.0)	67.8 (58.6)	.936*
TNF-α : IL-10	0.48 (0.51)	0.32 (0.23)	.472*
IL-1β : IL-10	0.0001 (0.01)	0.028 (0.05)	.009*†
IL-6 : IL-10	0.14 (0.18)	0.39 (0.44)	.005*†

MV, mechanical ventilation.

^*Mann-Whitney U rank test.

^†χ² test.

^‡P < .05.