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. Author manuscript; available in PMC: 2014 Apr 14.
Published in final edited form as: Laryngoscope. 2013 Oct 2;124(3):E56–E63. doi: 10.1002/lary.24326

Fig. 1.

Fig. 1

Multiple sequence alignment of the regulators of G protein signaling (RGS) domain of RGS21 and other RGS family members. Multiple sequence alignment (MSA) of the human RGS domains from RGS21, RGS2, RGS4, RGS20, RGS19, RGS12, RGS14, RGS7, and RGS9. RGS domains are frequently subdivided into nine subfamilies; highlighted in the MSA are members of the R4, R7, R12, and RZ families. The “consensus” amino acids are identified by ClustalX41 as either similar “*” or identical “.”. The secondary structure is annotated above the MSA based on the crystal structure of RGS2 (PDB ID: 2V4Z).39 Mutation to arginine 129 of RGS21, highlighted by a star, is predicted to abolish binding to Gα subunits.