Figure 3.

The resorption of VEGF-filled subretinal blebs. (A) In Dutch Belted rabbits, VEGF filling exhibited a concentration-dependent reduction in the rate of resorption compared with both PBS and albumin. As 10 μg/mL VEGF reduced the resorption rate more than 100 μg/mL albumin, the response to VEGF was beyond the one expected from oncotic forces alone. (B) The concentration-response curve exhibited sigmoid characteristics with a unitary slope. The EC₅₀ concentration for VEGF was equal to 4.9 μg/mL (log EC₅₀ = −5.3 ± 0.15). IOP was set at 10 mm Hg. Values are expressed as SEM; n = 3 to 4; **P < 0.01, ***P < 0.001.