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. 2014 Apr 9;55(4):2269–2275. doi: 10.1167/iovs.13-13334

Figure 4.

Figure 4

VEGF receptor specificity. Blebs filled with PlGF (a selective VEGF-R1 agonist) showed no significant difference in rate of resorption when compared with albumin-filled blebs, while VEGF (a nonselective VEGF receptor agonist) significantly reduced the resorption. Moreover, 1-hour intravitreal pretreatment with 10 μL of 10 μM ZM323881 (a specific VEGF-R2 antagonist) resulted in a rate of VEGF-filled bleb resorption that was not significantly different from the rate of albumin-filled bleb resorption. Both the agonist and antagonist experiments indicate a VEGF-R2–specific response. Concentrations were 100 μg/mL; **P < 0.01. Values are expressed as SEM; n = 3 to 4.