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. 2014 Apr 9;55(4):2269–2275. doi: 10.1167/iovs.13-13334

Figure 5.

Figure 5

Fluorescein angiogram post subretinal bleb injections. Fluorescein angiograms were performed following the creation of approximately equal size side-by-side VEGF- (red arrow) and albumin-filled blebs (white arrow) at equal 100 μg/mL concentrations. Blebs were injected in the absence (A–C) or the presence of 10 μL of 10 μM ZM323881 administered 1 hour before bleb injection (D–F). The infrared fundus images (A, D) show the blebs immediately prior to the intravenous injection of fluorescein. Representative fluorescence (λexc = 488) images taken consecutively at 20 seconds (B, E) and 30 seconds (C, F) post intravenous injection of fluorescein. (G) The total fluorescence (arbitrary unit) of blebs filled with VEGF (▪, kv), albumin (▴, kn), and VEGF with ZM323881 in the vitreous (•, kv+i) after intravenous injection of fluorescein exhibits linear early-phase kinetics. The k values represent the rate of fluorescence accumulation.