Table IV.

Empirical power across simulation replicates for gene-wise testing at Bonferroni corrected α = 0.05 (0.05/597 ≈ 8.38e-05) for all simulation scenarios and methods. The methods with the highest power per scenario are highlighted in bold (C-alpha was ignored due to its high Type I error rate).

Simulation Scenario			Methods
			EB-SGL	EB-SGL (no sing)	GB-L	GB-L (no sing)	SKAT	SKAT-O	WSS	C-alpha	CAST
Causal Variant %	OR model	Causal variants
40	Fixed	Random	0.002	0.088	0.102	0.231	0.635	0.661	0.533	0.744	0.394
		Exon	0.012	0.081	0.065	0.135	0.349	0.369	0.390	0.440	0.008
	MAF	Random	0.080	0.297	0.538	0.722	0.754	0.903	0.802	0.787	0.767
		Exon	0.198	0.339	0.516	0.676	0.398	0.614	0.561	0.540	0.228
20	Fixed	Random	0.001	0.007	0.000	0.004	0.184	0.177	0.200	0.205	0.000
		Exon	0.001	0.023	0.006	0.029	0.383	0.378	0.370	0.416	0.004
	MAF	Random	0.004	0.008	0.115	0.259	0.129	0.130	0.186	0.206	0.004
		Exon	0.040	0.137	0.142	0.400	0.432	0.500	0.401	0.491	0.113