Figure 2.

Regulation of integrin activation. Integrin activation may be regulated by post-translational modifications of the tail (e.g., phosphorylation) and through competition between activators and inhibitors for binding the β-tail. Inhibitors of integrin activation may be competed off integrin tails by other intracellular proteins (e.g., migfilin–filamin and Krit1–ICAP1 binding).