Figure 1.

Structural comparison of melittin and MelP5. The sequences of melittin and MelP5 are shown at the top. Residues with numbers are those that were varied in the library from which MelP5 was selected. The helical wheel diagrams show the spatial arrangement of the side chains under the assumption of an ideal helix formed by all the residues. Gray symbols are hydrophobic residues, blue symbols are basic residues, and orange symbols are polar residues. Symbols outlined in red (right) are those for which a variation was selected during screening.