Figure 1.
Hematoxylin and eosin staining of scarless E16.5 fetal wounds. Black arrows indicate India ink tattoo made at the time of wounding to demonstrate scarless wound location. Healed wounds (A, C) at 72 h (100×). The epidermal appendage (developing hair follicles) pattern shows numerous appendages directly in the healed wound. Magnified views of the same wounds (B, D) showing epidermal appendages (open arrows) within the wound site (200×). No inflammatory infiltrate is present. Reprinted with permission from Beanes et al.3 E16.5 is embryonic day 16.5, with day 0.5 defined as the morning after nocturnal conception. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound