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. Author manuscript; available in PMC: 2014 Apr 14.
Published in final edited form as: J Neurochem. 2007 Nov 6;104(4):1006–1019. doi: 10.1111/j.1471-4159.2007.05029.x

Fig. 7.

Fig. 7

Only the D1β RSA can produce significant uncoupling of the D1βPan receptor from Gs and Gz. The left panels show the effect of each RSA on D1βPan receptor-G protein coupling. Gs (a) or Gz (c) activities were measured in HEK D1αPan membrane preparations in the presence (+) or absence (−) of 10−5mol/L DA and 300 ng/mL of an RSA as indicated under each bar. Asterisks (*) indicate a significant difference from no DA no RSA (p < 0.05). Data represent the mean ± SEM, n ≥ 3. The right panels show that RSA uncoupling exhibits a dose-dependency. Gs (b) or Gz (d) activities were measured in HEK D1βPan membrane preparations in the presence of 10−5mol/L DA and increasing concentrations of an RSA (D1α, open triangles; D1β, open squares, D2α open circles). Data represent the mean ± SEM, n ≥ 3.