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. Author manuscript; available in PMC: 2014 Apr 14.
Published in final edited form as: J Med Chem. 2013 Aug 21;56(17):6803–6818. doi: 10.1021/jm400619b

Figure 2.

Figure 2

Selected reported fluorescently labeled Hsp90 inhibitors for use in FP (a) or flow cytometry and fluorescent microscopy (b). Arrow indicates point of attachment to ligand of linker-fluorophore. (c) Design of the FP probe based on the Hsp90 inhibitor 4. (d) Probe 16a docked into the Hsp90α ATP binding pocket (PDB ID: 2FWZ) as generated by Glide (version 5.0). Modeling shows potential steric clash between probe and Leu107 for linkers containing less than three carbons.