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. 2014 Jan 23;42(7):4406–4413. doi: 10.1093/nar/gkt1412

Figure 2.

Figure 2.

Rev3 deficiency affects both TC-NER and GG-NER. All cell lines were cultured under low-serum conditions that reduce, rather than abolish (Supplementary Figure S1), proliferation of Rev3−/− MEFs. (A) Profiles of repair replication in wild-type and Rev3−/− MEF line 8, 3 h following exposure to 10 J/m2 UV-C. Repair replication was normalized to the amount of parental DNA in the gradient. (B) Relative repair replication in wild-type and Rev3−/− MEF line 8. Repair replication in wild-type cells was set at 100%. Repair replication was measured thrice. (C) Recovery of RNA synthesis in wild-type and five independent Rev3−/− MEF lines following exposure to 10 J/m2 UV-C. RNA synthesis in unexposed cells was set at 100%. Mean ± SEM.